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Biomédica (Bogotá) ; 37(3): 303-307, jul.-set. 2017. tab, graf
Article in Spanish | LILACS | ID: biblio-888470

ABSTRACT

Resumen Se reporta el caso de un paciente de sexo masculino, de 61 años de edad, quien ocho meses después de someterse a un trasplante de corazón presentó una enfermedad sistémica con compromiso del sistema nervioso central y del sistema inmunológico, así como de pulmón, riñón, colon y piel, y a quien finalmente se le diagnosticó toxoplasmosis diseminada, a pesar de haber recibido profilaxis con trimetoprim-sulfametoxazol, debido a que el órgano provenía de un donante positivo para toxoplasmosis siendo él un receptor negativo. Se discuten las opciones de profilaxis en nuestro medio.


Abstract We report the case of a 61 year-old male who underwent heart transplantation eight months before developing a systemic condition with central nervous system, lung, kidney, colonic, cutaneous, and hematologic involvement, found to be secondary to a systemic toxoplasmosis despite co-trimoxazole prophylaxis in a previous-to-transplant seronegative patient receiving a heart from a seropositive donor. A review of prophylactic options in our environment is discussed.


Subject(s)
Humans , Male , Middle Aged , Postoperative Complications/etiology , Toxoplasmosis/transmission , Heart Transplantation , Antiviral Agents/therapeutic use , Plasma Exchange , Postoperative Complications/parasitology , Postoperative Complications/prevention & control , Recurrence , Tissue Donors , Viremia/drug therapy , Viremia/transmission , Antibodies, Protozoan/blood , Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosage , Toxoplasmosis/prevention & control , Immunoglobulins, Intravenous/therapeutic use , Combined Modality Therapy , Cytomegalovirus Infections/drug therapy , Cytomegalovirus Infections/transmission , Disease Progression , Seroconversion , Immunosuppressive Agents/adverse effects
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